2010 was the year that marked Interplay's return into video gaming. While Interplay did not ldevelop any new games themselves, they had announced themselves to be hard at work on Fallout Online. This started the Interplay-Bethesda Lawsuit.

Interplay launched the Discovery program in 2010. Two games were released through the Discovery program: Pinball Yeah! and Tommy Tronic.

This marked Interplay's partnership with two new companies: Coderunners and Oasis Games.